2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-122140
    ACG548B 795316-16-4 99.72%
    ACG548B (compound 24) is a potent inhibitor of acetyl- and butyrylcholinesterase (AChE and BChE) with IC50s of 1.78 and 0.496 μM, respectively. ACG548B has higher AChE affinity and selectivity over BChE and ChoK (choline kinase).
    ACG548B
  • HY-122152
    Spiclomazine hydrochloride 27007-85-8 98%
    Spiclomazine hydrochloride (APY-606) is an antipsychotic and antitumor agent. Spiclomazine hydrochloride inhibits KRas. Spiclomazine hydrochloride induces cancer cell apoptosis.
    Spiclomazine hydrochloride
  • HY-122216
    LY 88329 78693-86-4 98%
    LY 88329 is a potent narcotic antagonist.
    LY 88329
  • HY-122231
    MRS3558 793695-40-6 98%
    MRS3558 is a potent and selective A3AR agonist, with Ki values of 0.6 nM for humans and 0.9 nM for rats, making it suitable for research in the fields of neuropathic pain and anesthesia.
    MRS3558
  • HY-122232
    SW083688 422281-45-6 98%
    SW083688 is a potent, highly selective TAOK2 (Thousand-And-One Kinase 2) inhibitor (IC50 values = 1.3 umol/L).
    SW083688
  • HY-122271
    Safrazine hydrochloride 7296-30-2 98%
    Safrazine Hydrochloride is a monoamine oxidase inhibitor with irreversible activity. It is mainly used to inhibit depression and other mood disorders. As a compound, its mechanism is to increase the level of monoamine neurotransmitters in the body by blocking the activity of monoamine oxidase, thereby improving mood and psychological state.
    Safrazine hydrochloride
  • HY-122278
    Melevodopa 7101-51-1
    Melevodopa is an effervescent levodopa (HY-N0304) prodrug. Levodopa is an orally active metabolic precursor of neurotransmitters dopamine and has anti-allodynic effects and the potential for Parkinson's disease.
    Melevodopa
  • HY-122294
    Rociverine 53716-44-2 98%
    Rociverine is an anticholinergic compound with smooth muscle relaxant activity. Rociverine showed different binding modes in five cloned muscarinic receptors. The cis stereoisomer of Rociverine showed a higher affinity change compared to the trans stereoisomer. The (1R,2R) configuration of Rociverine showed significantly higher affinity, even up to 240 times. The (1S,2S) configuration of Rociverine is very important for binding selectivity.
    Rociverine
  • HY-122300
    R-(-)-Oxaprotiline hydrochloride 76496-69-0 98%
    R-(-)-Oxaprotiline (Levoprotiline) hydrochloride is the R-enantiomer of Oxaprotiline. Oxaprotiline is a tetracyclic antidepressant agent.
    R-(-)-Oxaprotiline hydrochloride
  • HY-122303
    4-hydroxy DiPT hydrochloride 63065-90-7 98%
    4-hydroxy DiPT hydrochloride is an 5-HT2A agonist that induces the head-twitch response (HTR) in mice, indicating psychoactivity.
    4-hydroxy DiPT hydrochloride
  • HY-122347
    Orvepitant 579475-18-6 98%
    Orvepitant (GW823296) is a compound with the ability to inhibit pruritus induced by cancer epidermal growth factor receptor inhibitor (EGFRI) and is a neurokinin-1 receptor antagonist.
    Orvepitant
  • HY-122367
    Neoxaline 909900-78-3 98%
    Neoxaline is an alkaloid produced by Aspergillus japonicus. Neoxaline does not possess antimicrobial activities, but weakly stimulates the central nervous system.
    Neoxaline
  • HY-12236B
    (R)-SKF-81297 hydrobromide 253446-15-0 98%
    (R)-SKF-81297 hydrobromide is the R-enantiomer of SKF-81297 (HY-12236A). SKF-81297 is a selective agonist for dopamine D1 receptor.
    (R)-SKF-81297 hydrobromide
  • HY-122495
    rel-Quinpirole dihydrochloride 73625-62-4 98%
    rel-Quinpirole (rel-LY 171555) dihydrochloride, an ergot compound, is a selective dopamine (DA) D2 receptor agonist. rel-Quinpirole dihydrochloride can be used for research on neurological diseases.
    rel-Quinpirole dihydrochloride
  • HY-122504
    Linoleoyl glycine 2764-03-6 98%
    Linoleoyl glycine is a modified polyunsaturated fatty acid. Linoleoyl glycine has activating effects on human KCNQ1/KCNE1 (hKCNQ1/hKCNE1) channels expressed in Xenopus oocytes.
    Linoleoyl glycine
  • HY-122510
    Atropine oxide 4438-22-6 98%
    Atropine Oxide (Atropine oxidation), a derivative of Atropine, acts as a competitive antagonist to the muscarinic acetylcholine receptors M1, M2, M3, M4, and M5, and is utilized in the treatment of specific nerve agent and pesticide poisonings.
    Atropine oxide
  • HY-122612
    SB-258585 209480-63-7 98%
    SB-258585 is a selective ligand with high affinity for the 5-HT6 receptor, with a pKi value of 8.53.
    SB-258585
  • HY-122681
    SR-16435 857262-16-9 98%
    SR-16435 is a nociceptin/orphanin FQ (NOP)/μ-opioid receptor partial agonist, with high binding affinity (NOP receptor Ki=7.49; μ-Opioid receptor Ki=2.70). SR-16435 can relieve pain.
    SR-16435
  • HY-122704
    Surfen 3811-56-1 98%
    Surfen is a potent heparan sulfate antagonist. Surfen inhibits FGF2 binding and signal transduction. Surfen binds to glycosaminoglycans and reduces tau hyperphosphorylation. Surfen inhibits the activity of recombinant uronyl 2-O-sulfotransferase with an IC50 of approximately 2 μM. Surfen inhibits HSV-1 viral infection. Surfen inhibits neural differentiation, delays remyelination, and alleviates EAE.
    Surfen
  • HY-122761
    Quifenadine 10447-39-9 98%
    Quifenadine (Compound 3a), the hydroxyl-(diphenyl)methyl quinuclidine derivative, is a M3 receptor antagonist with an IC50 value > 1000 nM. Quifenadine can be used for the research of neurological disease.
    Quifenadine
Cat. No. Product Name / Synonyms Application Reactivity